Drug trials in DLB

Dag Aarsland

The presentation will review recently published and ongoing clinical trials in prodromal and manifest DLB. A systematic review will be conducted by examining relevant literature databases and 3 international trial registries: ClinicalTrials.gov, the European Union Drug Regulating Authorities Clinical Trials Database, and the International Clinical Trials Registry Platform, to identify drugs in trials in DLB. Trials will be categorized according to trial phase, and the compounds according to disease modifying or symptomatic, and specific mechanisms listed.

Challenges in conducting clinical trials will be briefly discussed, including the need for disease-specific outcome measures and biomarkers, and improving representation of global and diverse populations.